Calmodulin antagonists inactivate glibenclamide-sensitive K+ channels
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منابع مشابه
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
The effects of nicorandil on ionic currents recorded from single smooth muscle cells of pig proximal urethra were investigated using patch-clamp techniques. Tension measurement was also performed to study the effects of nicorandil on the resting tone of pig urethra. Nicorandil produced a concentration-dependent sustained outward current that was suppressed by glibenclamide at -50 mV and was car...
متن کاملEffects of levcromakalim and nucleoside diphosphates on glibenclamide-sensitive K+ channels in pig urethral myocytes.
1. Effects of levcromakalim and nucleoside diphosphates (NDPs) on both membrane currents and unitary currents in pig proximal urethra were investigated by use of patch clamp techniques (conventional whole-cell configuration, nystatin perforated patch, cell-attached configuration and inside-out patches). 2. Levcromakalim produced a concentration-dependent outward current at a holding potential o...
متن کاملGlibenclamide blocks volume-sensitive Cl- channels by dual mechanisms.
To study the mechanisms of glibenclamide actions on volume-sensitive Cl-channels, whole cell patch-clamp studies were performed at various pH levels in human epithelial Intestine 407 cells. Extracellular application of glibenclamide reversibly suppressed volume-sensitive Cl- currents in the entire range of voltage examined (-100 to +100 mV) and accelerated the depolarization-induced inactivatio...
متن کاملActivation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia.
BACKGROUND Cardiac ATP-sensitive K(+) channels have been suggested to contribute to the adaptive physiological response to metabolic challenge after β-adrenoceptor stimulation. However, an increased atrial K(+)-conductance might be expected to be proarrhythmic. We investigated the effect of ATP-sensitive K(+) channel blockade on the electrophysiological responses to β-adrenoceptor-induced metab...
متن کاملGlibenclamide blocks volume-sensitive Cl2 channels by dual mechanisms
Liu, Yan, Shigetoshi Oiki, Takehiko Tsumura, Takahiro Shimizu, and Yasunobu Okada. Glibenclamide blocks volume-sensitive Cl2 channels by dual mechanisms. Am. J. Physiol. 275 (Cell Physiol. 44): C343–C351, 1998.—To study the mechanisms of glibenclamide actions on volume-sensitive Cl2 channels, whole cell patch-clamp studies were performed at various pH levels in human epithelial Intestine 407 ce...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)49195-6